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. 2002 Feb 20;70(4):1015–1022. doi: 10.1086/339518

Figure 5.

Figure 5

Normal response of the cells from patient 1 (upright triangle) and patient 2 (inverted triangle) to MMC. A, The G2-phase proportion of primary lymphocytes of patient 2, relative to their corresponding growth fraction at 10 ng/ml MMC, was 0.30. This ratio was within the limits of 23 normal control lymphocyte cultures (mean ± 1 SD = 0.25 ± 0.05; range 0.18–0.34), as opposed to 35 MMC-sensitive FA cultures (mean ± 1 SD = 0.63 ± 0.06; range 0.47–0.73). All cultures revealed similar growth fractions (percent noncycling cells, patient 2: 40%; mean ± 1 SD of the healthy control subjects 31.8 ± 13.1%; range 13.4%–71.2%; mean ± 1 SD of the FA lymphocytes: 39.7% ± 15.7%; range 13.4%–81.1%). B, The G2-phase proportions of the lymphoblast lines of both patients relative to their corresponding growth fractions at 10 ng/ml MMC were 0.24 and 0.27, respectively. These ratios were within the range of 12 normal control lines (mean ± 1 SD = 0.23 ± 0.04; range 0.18–0.31) as opposed to 5 MMC-sensitive FA lines (mean ± 1 SD = 0.45 ± 0.04; range 0.41–0.51). The lines of both patients revealed similar growth fractions (percent noncycling cells: patient 1, 15.9%; patient 2, 18.1%) as the normal control lines (mean ± 1 SD = 23.0% ± 8.9%; range 4.7%–38.5%).