Table 2.
Adverse events
| Grade 3 or 4 toxicity* | ICE (56 courses) | aICE (138 courses) | GVD (132 courses) | TLI (56 patients) | CBV (29 patients) |
|---|---|---|---|---|---|
| Febrile neutropenia | 3 | 22 | 0 | 0 | 0 |
| Catheter-related infection/thrombosis | 1 | 8 | 0 | 0 | 0 |
| Acute renal failure | 1 | 0 | 1 | 0 | 0 |
| Clostridium difficile | 1 | 0 | 0 | 0 | 2 |
| Viral meningitis | 1 | 0 | 0 | 0 | 0 |
| Pneumonia | 1 | 1 | 0 | 0 | 0 |
| Pulmonary embolism | 0 | 1 | 0 | 0 | 0 |
| Cellulitis | 0 | 1 | 0 | 0 | 0 |
| Anaphylaxis | 0 | 0 | 1 | 0 | 0 |
| Radiation esophagitis | 0 | 0 | 0 | 1 | 0 |
| Depression | 0 | 0 | 0 | 1 | 1 |
| Radiation pneumonitis | 0 | 0 | 0 | 1 | 0 |
| Disseminated zoster | 0 | 0 | 0 | 1 | 0 |
| Autologous graft vs host | 0 | 0 | 0 | 1 | 0 |
| Pericardial tamponade | 0 | 0 | 0 | 1 | 0 |
| Multisystem organ failure | 0 | 0 | 0 | 1 | 0 |
| Myelodysplasia | 0 | 0 | 0 | 0 | 1 |
*
Once a patient failed either ICE or GVD, the patient was taken off study and subsequent treatment was not dictated in the protocol patients.