Fig. 6.

Flexibility of individual residues in bMGL. A) Backbone root mean square deviation of bMGL H257 during a 90 ns molecular dynamics simulation. The backbone RMSD of the cap region relative to the open conformation is shown in black and relative to the closed confirmation in light grey, the core region of the protein is shown in dark grey (bottom line). B) Backbone root means square fluctuations (RMSF) per residue of bMGL during a 90 ns molecular dynamics simulation. The cap region from Ile119 to Thr164 is indicated with a dotted line.