Skip to main content
. 2012 Oct;1818(10):2465–2475. doi: 10.1016/j.bbamem.2012.01.018

Fig. 2.

Fig. 2

Model of competition between CFH and CFHR1/3 on MDA-decorated surfaces. (A) CFH binds to MDA on the surface of apoptotic cells, where it promotes factor I-mediated cleavage of C3b into iC3b. (B) CFHR1 and 3 lack a complement regulatory function but contain potential MDA-binding motifs and may therefore compete with CFH for MDA binding, leading to reduced anti-inflammatory iC3b generation on MDA-decorated surfaces.