Common |
Cushing’s syndrome or exogenous corticosteroid use (>5 mg/day for >3 months) |
Excessive alcohol use (more than two standard drinks per day) |
Primary or secondary hypogonadism |
Inadequate calcium intake (<600 mg/day) |
Vitamin D deficiency/insufficiency |
Tobacco |
Family history |
Less common |
Low body mass index (<20) |
Lack of exercise or excessive exercise |
Antiepileptic drugs (phenytoin, phenobarbitone, primidone, carbamazepine) |
Thyrotoxicosis |
Primary hyperparathyroidism |
Type 1 and type 2 diabetes mellitus |
Chronic liver or kidney disease |
Malabsorption, including coeliac disease |
Hypercalciuria |
Rheumatoid arthritis or ankylosing spondylosis |
Rare |
Multiple myeloma |
Human immunodeficiency virus infection or its treatment with protease inhibitors (tenofovir) |
Mastocytosis |
Immunosuppressive therapy (cyclosporin, tacrolimus) |
Osteogenesis imperfect |