Table 1.

Hemodynamic parameters at baseline and 10 weeks after MI.

	Baseline		10 weeks after MI
	WT	PDE5-TG	WT	PDE5-TG
HR (bpm)	463±12	463±9	475±9	472±14
ESV (µL)	15±2	17±1	39±4*	57±5*,†
EDV (µL)	26±2	29±2	48±4*	65±6*,†
ESP (mmHg)	73±1	79±4	66±2	70±3
EDP (mmHg)	3.5±0.4	3.6±0.6	3.5±0.9	6.5±1.3
CO (mL/min)	6.8±0.4	7.2±0.5	5.3±0.6	4.9±0.8
SW (mmHg.µL)	941±83	1002±89	524±95*	372±86*
Ea (mmHg/µL)	5.3±0.3	5.2±0.3	7.4±1	10.2±3
PAMP (mW/µL2)	94±15	84±14	25±5*	13±3*
Tau (ms)	7.3±0.4	7.4±0.4	8.2±0.5	10.4±0.5*,†
Slope of EDPVR	0.26±0.02	0.25±0.03	0.33±0.05	0.70±0.17*

HR, heart rate; ESV and EDV, end-systolic and end-diastolic volume; ESP and EDP, end-systolic and end-diastolic pressure; CO, cardiac output; SW, stroke work; Ea, effective arterial elastance; PAMP, preload-adjusted maximal power; Tau, isovolumic relaxation time (Weiss); Slope of EDPVR, slope of end-diastolic pressure-volume relationship.

^*P<0.05 versus same genotype at baseline,

^†P<0.05 versus WT after MI