Table 2.
Factors associated with disease-specific survival after 3-year survival
| Factor (n) | 5-year conditional DSSa (%) | Univariate P | Multivariate P, HR (95% CI) |
|---|---|---|---|
| Gender | 0.73 | – | |
| Female (n = 214) | 65 | ||
| Male (n = 290) | 69 | ||
| Age, years | 0.54 | – | |
| ≤70 (n = 381) | 66 | ||
| >70 (n = 123) | 72 | ||
| Primary site | 0.46 | – | |
| Colon (n = 373) | 69 | ||
| Rectum (n = 166) | 65 | ||
| T stage of primary tumour | 0.79 | – | |
| 1, 2 (n = 89) | 70 | ||
| 3, 4 (n = 389) | 67 | ||
| N stage of primary tumour | 0.09 | 0.56 | |
| N0 (n = 232) | 72 | ||
| N1,2 (n = 272) | 64 | ||
| Lymphovascular invasion of primary tumour | 0.47 | – | |
| Present (n = 115) | 64 | ||
| Absent (n = 258) | 71 | ||
| Perineural invasion of primary tumour | 0.05 | 0.83 | |
| Present (n = 59) | 53 | ||
| Absent (n = 272) | 71 | ||
| Tumour grade of primary tumour | 0.54 | – | |
| Low (n = 15) | 65 | ||
| Moderate (n = 413) | 67 | ||
| Poor (n = 32) | 63 | ||
| DFI before liver metastasis, months | 0.07 | 0.04, 1.4 (1.0–2.1) | |
| 0–12 (n = 277) | 63 | ||
| >12 (n = 227) | 73 | ||
| Size of largest metastasis, cm | 0.16 | – | |
| <5 (n = 370) | 69 | ||
| ≥5 (n = 134) | 63 | ||
| Number of liver metastases | 0.67 | – | |
| 1 (n = 269) | 69 | ||
| >1 (n = 235) | 65 | ||
| Extent of liver resection | 0.91 | – | |
| Minor (n = 215) | 67 | ||
| Major (n = 289) | 68 | ||
| Extrahepatic disease resected | 0.45 | – | |
| Yes (n = 14) | 67 | ||
| No (n = 490) | 80 | ||
| Pre-operative CEA level, ng/ml | 0.005 | <0.01, 2.1 (1.2–3.8) | |
| <200 (n = 421) | 70 | ||
| ≥200 (n = 37) | 45 | ||
| Clinical Risk Score: | 0.19 | – | |
| Low (0–2) (n = 386) | 69 | ||
| High (3–5) (n = 118) | 62 | ||
| Pre-liver resection chemotherapy | 0.45 | ||
| Yes (n = 391) | 64 | ||
| No (n = 107) | 68 | – | |
| Adjuvant systemic chemotherapy | 0.69 | – | |
| Yes (n = 433) | 68 | ||
| No (n = 47) | 63 | ||
| Adjuvant hepatic arterial chemotherapy | 0.81 | – | |
| Yes (n = 160) | 65 | ||
| No (n = 336) | 69 | ||
| Recurrence within 3 years of a liver resection | <0.0001 | <0.0001, 8.6 (5.6–13.7) | |
| Yes (n = 232) | 38 | ||
| No (n = 272) | 90 | ||
a
Defined as the probability of surviving another 5 years, having already survived 3 years.
DSS, disease-specific survival; HR, hazard ratio; CI, confidence interval; CEA, carcinoembryonic antigen; DFI, disease-free interval.