Table 2.
Papillary Thyroid Cancer–Related Mortality, Person-Years of Follow-up, and Hazard Ratios for BRAF V600E Mutation-Positive vs Mutation-Negative Patients
| Type of Papillary Thyroid Cancer | Mortality, No./Total (%)
|
Person- Years of Follow-up | Deaths per 1000 Person-Years (95% CI)
|
Hazard Ratio (95% CI)
|
|||||
|---|---|---|---|---|---|---|---|---|---|
| Overall | BRAF V600E– Positive | BRAF V600E– Negative | P Value | BRAF V600E– Positive | BRAF V600E– Negative | Unadjusted | Adjusteda | ||
| All types | 56/1849 (3.0) | 45/845 (5.3) | 11/1004 (1.1) | <.001 | 7856.75 | 12.87 (9.61–17.24) | 2.52 (1.40–4.55) | 5.31 (2.74–10.30) | 2.66 (1.30–5.43) |
|
| |||||||||
| Conventional | 39/1233 (3.2) | 33/659 (5.0) | 6/574 (1.0) | <.001 | 5466.75 | 11.80 (8.39–16.60) | 2.25 (1.01–5.00) | 5.63 (2.34–13.51) | 3.53 (1.25–9.98) |
|
| |||||||||
| Follicular variant | 6/411 (1.5) | 4/82 (4.9) | 2/329 (0.6) | .02 | 1572.25 | 11.21 (4.21–29.86) | 1.65 (0.41–6.58) | 6.02 (1.10–32.96) | 1.67 (0.06–47.49) |
a
Proportional hazards regression model adjusted for patient sex and age at diagnosis and stratified by medical center.