Table 1.
Clinician and Antipsychotic Treatment Characteristics in High vs. Low Antipsychotic Polypharmacy Prescribers (APP)
| Characteristic | (N=217) | >50% APP (n=90) |
≤50% APP (n=127) |
P-value | >10% (N=193) |
≤10% (N=24) |
P-value |
|---|---|---|---|---|---|---|---|
| Prescriber Demographics | |||||||
| Attending clinician (N, %) | 190 (87.6) |
82 (91.1) | 108 (85.0) | 0.18 | 172 (89.1) |
18 (75.0) | 0.048 |
| Years of practice (years±SD) |
10.5±8.6 | 11.7±10.6 | 9.7±6.9 | 0.11 | 10.7±8.8 | 8.8±6.1 | 0.31 |
| Practice at psychiatric hospital |
164 (75.6) |
77 (85.6) | 87 (68.5) | 0.004 | 149 (77.2) |
15 (62.5) | 0.11 |
|
Antipsychotic Cotreatment
Frequency (% ± SD) |
|||||||
| Any combination | 48.3±13.6 | 72.4±9.8 | 31.2±15.8 | <0.001 | 53.4±20.9 | 7.2±3.4 | <0.001 |
| SGA+SGA | 47.9±25.3 | 48.9±24.2 | 47.2±26.1 | 0.63 | 48.1±25.7 | 46.0±22.7 | 0.71 |
| SGA+FGA | 35.4±28.4 | 33.5±28.0 | 36.7±28.6 | 0.43 | 35.0±2.1 | 38.5±5.8 | 0.56 |
| FGA+FGA | 17.2±18.1 | 18.1±18.2 | 16.5±18.0 | 0.52 | 17.4±18.4 | 15.4±15.4 | 0.61 |
|
Antipsychotic Cotreatment
History (% ± SD) |
|||||||
| Patients successfully switched to monotherapy |
28.3±19.1 | 28.4±19.2 | 28.3±18.9 | 0.97 | 28.1±19.6 | 29.8±14.1 | 0.69 |
| Patients unsuccessful switch to monotherapy |
37.0±21.8 | 38.4±20.5 | 35.9±22.7 | 0.41 | 37.7±22.4 | 31.0±15.7 | 0.16 |
| Switch to monotherapy not attempted |
35.2±27.4 | 33.3±27.2 | 36.6±27.6 | 0.39 | 34.7±28.1 | 39.2±21.5 | 0.45 |
|
Preferred Antipsychotic Class
Combinations (N, %) |
|||||||
| No preference | 40 (19.0) | 22 (25.3) | 18(14.5) | 0.032* | 37 (37.0) | 3 (21.4) | 0.16 |
| SGA + FGA | 102 (53.7) |
40 (53.3) | 62 (53.9) | 0.92 | 55 (32.7) | 11 (50.0) | 0.27 |
| SGA + SGA | 69 (36.3) | 23 (30.7) | 46 (40.0) | 0.47 | 89 (53.0) | 13 (59.1) | 0.86 |
| *Became insignificant after Bonferroni correction |
Chi2 or ANOVA/Wilcoxon rank sum test were used to detect differences between groups.