Table 1.
Set 1 | |||
---|---|---|---|
Group | Treatment plan | Dose, mg/kg | |
T1 | Saline control | Saline (control) | 0 |
T2 | BOP control | BOP | 35 (1st week) / 20 (next 4 weeks) |
T3 | Low dose ACS | ASP+CUR+SFN | 20 + 45 + 1.6 |
T4 | Medium dose ACS | ASP+CUR+SFN | 70 + 150 + 5 |
T5 | High dose ACS | ASP+CUR+SFN | 200 + 450 + 16 |
Set 2 | |||
T6 | Saline control | Saline (Control) | 0 |
T7 | Blank SLN control | Blank SLN (Vehicle control) | 0 |
T8 | BOP control | BOP | 35(1st week) / 20(next 4 weeks) |
T9 | Low dose SLN ACS | ASP+CUR+SFN | 2 + 4.5 + 0.16 |
T10 | Medium dose SLN ACS | ASP+CUR+SFN | 7 + 15 + 0.5 |
T11 | High dose SLN ACS | ASP+CUR+SFN | 20 + 45 + 1.6 |
Abbreviations: ASP, aspirin; CUR, curcumin; SFN, sulforaphane; BOP, N-nitrosobis (2-oxopropyl) amine; SLN, solid lipid nanoparticles.