Table 1.
Morphometry | WT | MLP−/− | β1+/−MLP−/− | β2−/−/MLP−/− |
---|---|---|---|---|
BW (g) | 31.5±1.5 | 33.5±1 | 29.8±1.3 | 37.2±1.2* |
HW (mg) | 132.6±18 | 243.3±62* | 236.1±98* | 168.5±42 |
HW/BW (mg/g) | 4.2±0.1 | 6.9±0.7* | 7.2±0.5* | 4.9±0.3 |
LW/BW (mg/g) | 4.8±0.2 | 5.7±0.2 | 6.2±0.4* | 4.9±0.2 |
n | 8 | 6 | 11 | 8 |
Echocardiography | ||||
LVEDD (mm) | 3.4±0.1 | 5.2±0.2* | 5.9±0.4* | 3.9±0.2 |
LVESD (mm) | 1.8±0.1 | 4.2±0.3* | 4.7±0.4* | 2.4±0.2 |
LVPWD | 0.96±0.05 | 0.8±0.04* | 0.8±0.02* | 0.96±0.04 |
LVPWS | 1.24±0.05 | 0.99±0.06* | 1.00±0.03* | 1.19±0.04 |
n | 8 | 14 | 10 | 23 |
BW: body weight; HW: heart weight; LW: lung weigh; LVEDD: left ventricular end-diastolic dimension; LVESD: left ventricular end-systolic dimension; LVPWD: left ventricular posterior wall in diastole; LVPWS: left ventricular posterior wall in systole; n: number of mice.
p<0.05 vs WT.