Figure 2.

Reduced proliferation, high grade dysplasia and nuclear β-catenin translocation in polyps of L-Fabp^−/−Apc^Min/+ mice. A, reduction in % of BrdU-positive cells/polyp. B, representative BrdU staining (brown nuclei) of proximal small intestine polyps. C, reduction in proportion of polyps with high-grade dysplasia. D, representative example of high-grade dysplasia from Apc^Min/+ mice (left) versus low-grade dysplasia from L-Fabp^−/−Apc^Min/+ mice (right). E, reduction in nuclear β-catenin translocation. F, representative β-catenin staining (brown nuclei) of proximal small intestine polyps. ***, p ≤ 0.001.