Table 2.
Summary of protein, mRNA and FISH results for HER-2 FISH positive tumors that do not over-express HER-2 protein and comparison group of HER-2 FISH positive tumors that do over-express HER-2 protein
| ID number | Western | Western | IHC | FISH | FISH | FISH | RT-PCR | RT-PCR |
|---|---|---|---|---|---|---|---|---|
| GRB7 | HER2 | HER2 | HER2 | BAC 3079 | BAC 3014 | GRB7 | HER2 | |
| 016 | high | low | 1 + | 2.58 | NA | NA | low | low |
| 031 | high | low | Cyto Gran Stain | > 3.04 | 2.80 | 2.73 | high | low |
| 131 | high | low | 1 + | 2.52 | 1.98 | 1.94 | high | low |
| 412 | high | low | 1 + | 2.78 | 2.86 | 2.86 | high | low |
| 457 | high | low | Cyto Gran Stain | 5.21 | 5.27 | 5.32 | high | low |
| 517 | high | low | Cyto Gran Stain | > 3.39 | 2.78 | 2.89 | low | low |
| 213 | high | low | Cyto Gran Stain | 4.44 | 2.48 | 3.59 | high | high |
| 012 | high | high | 3 + | > 5.13 | NA | NA | high | high |
| 020 | high | high | 3 + | 5.28 | NA | NA | NA | NA |
| 276 | high | high | 3 + | 4.90 | NA | NA | NA | NA |
| 327 | high | high | 3 + | 4.48 | 3.77 | 3.77 | high | high |
| 334 | high | high | 3 + | 4.93 | NA | NA | high | high |
| 369 | high | high | 3 + | 4.98 | 4.06 | 4.02 | high | high |
| 433 | high | high | NA | 4.37 | 4.81 | 4.54 | high | high |
| 772 | high | high | NA | 4.59 | 5.18 | 5.18 | high | high |
FISH scores represent the ratio of signals derived from HER-2 region specific probes over that derived from the chromosome 17 centromeric region probe (D17Z1). NA = not analyzed.