Table 1.

Clinical Characteristics of the Studied GeneID Chinese Han Population

Characteristics	GeneID Discovery		p	GeneID Validation		p	GeneID Replication 1		p	GeneID Replication 2		p	GeneID Combined		p
	CAD	Control		CAD	Control		CAD	Control		CAD	Control		CAD	Control
Number of subjects	860	707	–	575	471	–	2,016	1,647	–	1,070	1,984	–	4,521	4,809	–
Age (years)a	59.4 ± 11.2	58.2 ± 13.7	0.12	60.8 ± 11.0	59.9 ± 11.5	0.24	60.5 ± 9.08	59.9 ± 8.49	0.14	60.2 ± 10.2	59.6 ± 9.12	0.10	60.2 ± 9.85	59.7 ± 9.25	0.10
Percent of subjects male	56.8	59.1	0.36	69.7	65.7	0.17	61.7	63.9	0.16	61.5	59.6	0.21	61.9	61.6	0.80
Percent of subjects smoking	44	19	0.00	21.7	6.4	0.00	24.1	0.4	0.00	23.8	7.1	0.00	27.5	5.8	0.00
BMI (kg/m2)	24.7 ± 3.49	23.8 ± 2.92	0.34	24.5 ± 2.80	23.7 ± 9.41	0.39	24.8 ± 2.93	23.5 ± 3.09	0.46	26.3 ± 2.10	25.7 ± 8.24	0.11	25.1 ± 3.31	24.5 ± 5.16	0.10
Hypertension (%)	61	29.6	0.00	48.6	16	0.00	69.6	1.2	0.00	49.3	11	0.00	60.5	10.7	0.00
DM	16.8	9.9	0.00	17.5	6	0.00	23.1	0.4	0.00	16.8	3	0.00	19.7	3.4	0.00
Tch (mmol/l)	4.49 ± 1.07	4.35 ± 0.89	0.00	4.59 ± 1.11	4.39 ± 0.93	0.00	4.57 ± 1.17	4.53 ± 0.85	0.13	4.69 ± 1.21	4.55 ± 0.88	0.00	4.58 ± 1.10	4.50 ± 0.73	0.00
TG (mmol/l)	1.84 ± 1.36	1.52 ± 0.88	0.00	1.92 ± 1.48	1.65 ± 0.90	0.00	1.86 ± 1.39	1.57 ± 0.89	0.00	1.74 ± 1.10	1.46 ± 0.70	0.00	1.84 ± 1.16	1.53 ± 0.65	0.00
HDL-c (mmol/l)	1.08 ± 0.24	1.11 ± 0.24	0.08	1.10 ± 0.21	1.16 ± 0.22	0.00	1.11 ± 0.23	1.14 ± 0.25	0.00	1.14 ± 0.27	1.23 ± 0.20	0.00	1.12 ± 0.32	1.18 ± 0.21	0.00
LDL-c (mmol/l)	2.66 ± 0.77	2.41 ± 0.83	0.01	2.57 ± 0.98	2.40 ± 0.82	0.00	2.60 ± 0.84	2.37 ± 0.84	0.00	2.67 ± 0.91	2.52 ± 0.65	0.00	2.60 ± 0.84	2.44 ± 0.60	0.00

The data are presented as the means ± standard deviation or percent.

^aAge for the case subject is at diagnosis; age for the control subject is at enrollment.