Table 2.

Allelic Association Analysis of rs7025417 in IL33 and rs11685424 in IL1RL1 with CAD in the GeneID Chinese Han Population

Population	n		Gene, SNP (Reference Allele)	Frequency		phwe	pobs	padj	OR (95%CI)
	Cases	Controls		Case	Control
GeneID Discovery	860	707	IL33, rs7025417T	0.585	0.516	0.259	1.02 × 10−4	1.38 × 10−4	1.32 (1.14–1.52)
			IL1RL1, rs11685424G	0.567	0.515	0.293	3.63 × 10−3	2.12 × 10−3	1.25 (1.08–1.44)
GeneID Validation	575	471	IL33, rs7025417T	0.584	0.486	0.4	7.42 × 10−6	7.69 × 10−6	1.49 (1.25–1.77)
			IL1RL1, rs11685424G	0.57	0.487	0.453	1.48 × 10−4	1.25 × 10−4	1.40 (1.18–1.67)
GeneID Replication 1	2,016	1,647	IL33, rs7025417T	0.589	0.528	0.008	2.28 × 10−7	2.32 × 10−7	1.28 (1.16–1.40)
			IL1RL1, rs11685424G	0.566	0.483	0.776	1.08 × 10−12	1.15 × 10−12	1.40 (1.28–1.53)
GeneID Replication 2	1,070	1,984	IL33, rs7025417T	0.594	0.497	0.367	4.39 × 10−13	1.06 × 10−12	1.47 (1.33–1.66)
			IL1RL1, rs11685424G	0.579	0.481	0.118	1.65 × 10−13	2.17 × 10−13	1.49 (1.34–1.65)
GeneID Combined	4,521	4,809	IL33, rs7025417T	0.591	0.509	0.001	1.41 × 10−27	1.19 × 10−28	1.39 (1.31–1.47)
			IL1RL1, rs11685424G	0.573	0.487	0.027	6.25 × 10−30	6.93 × 10−30	1.40 (1.32–1.48)
GeneID Anatomical CAD	1,598	4,809	IL33, rs7025417T	0.579	0.509	0.001	6.06 × 10−12	3.79 × 10−11	1.32 (1.22–1.44)
			IL1RL1, rs11685424G	0.565	0.487	0.027	2.37 × 10−14	2.73 × 10−13	1.36 (1.25–1.48)
GeneID Clinical CAD	2,923	4,809	IL33, rs7025417T	0.594	0.509	0.001	2.19 × 10−24	8.57 × 10−22	1.39 (1.30–1.49)
			IL1RL1, rs11685424G	0.573	0.487	0.027	4.73 × 10−25	9.48 × 10−22	1.39 (1.30–1.49)

Abbreviations are as follows: p_hwe, p value from Hardy-Weinberg equilibrium tests; p_obs, observed p value; p_adj, p value adjusted by covariates; OR, odds ratio after adjustment.