Table 3.
Interaction Analysis between rs7025417 in IL33 and rs11685424 in IL1RL1 under the Genotypic Model in the GeneID Combined Population
| Types | Case (%) | Control (%) | padj | OR (95% CI) |
|---|---|---|---|---|
| TT/GG | 675 (14.9) | 416 (8.7) | 8.90 × 10−21 | 4.98 (3.56-6.97) |
| TT/GA | 594 (13.1) | 479 (10.0) | 5.20 × 10−9 | 2.39 (1.78-3.20) |
| TT/AA | 210 (4.6) | 288 (6.0) | 3.53 × 10−2 | 1.43 (1.02-1.98) |
| TC/GG | 577 (12.8) | 490 (10.2) | 4.18 × 10−9 | 2.4 (1.79–3.22) |
| TC/GA | 1,345 (29.8) | 1,518 (31.6) | 5.00 × 10−6 | 1.92 (1.45–2.54) |
| TC/AA | 442 (9.8) | 524 (10.9) | 1.35 × 10−3 | 1.64 (1.21–2.21) |
| CC/GG | 190 (4.2) | 188 (3.9) | 2.23 × 10−3 | 1.71 (1.21–2.40) |
| CC/GA | 332 (7.3) | 499 (10.4) | 6.50 × 10−2 | 1.34 (0.98–1.83) |
| CC/AA | 156 (3.5) | 407 (8.5) | – | 1 |
| ADD/ADD | – | – | 2.81 × 10−32 | – |
The population CAD combined consisted of 4,521 cases and 4,809 controls. Abbreviations are as follows: padj, p value after adjustment for covariates, such as age, gender, smoking, BMI, hypertension, DM, Tch, TG, HDL-c, and LDL-c; ADD, additive model, rs7025417_TT/TC/CC, rs11685424_GG/GA/AA.