MRI and FDG-PET results for the comparison of three groups of AD patients, MCI converters (cMCI) and non-converters (ncMCI) split by age compared to the same group of control subjects. a) MRI (blue: atrophy) and FDG-PET (red: hypometabolism) results plotted onto an averaged brain. Overlapping results are displayed in violet. Results for differently aged subgroups are separated by rows. Results for different clinical groups are separated by columns. Cortical hypometabolism in ncMCI patients was restricted to the right hemisphere. In contrast, in both other groups the results were much more symmetric however with more extensive changes in the left hemisphere. b) Number of significant voxels (p = 0.001 uncorrected at voxel level and p = 0.05 FWE corrected at cluster level) detected in each comparison in FDG-PET (red) and MRI (blue). AD Alzheimer’s disease, FDG-PET [18F]fluorodeoxyglucose positron emission tomography, FWE family-wise error, MCI Mild Cognitive Impairment, MRI structural magnetic resonance imaging, * indicates a significant difference between modalities within the condition, ** indicates a significant difference to all other conditions within the modality. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)