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. Author manuscript; available in PMC: 2013 Oct 6.
Published in final edited form as: Biol Chem. 2011 Aug 30;392(11):973–981. doi: 10.1515/BC.2011.100

Table 1.

Analytical data and inhibition constants of synthesized furin inhibitors.

No. Structure HPLC (min) MS calc./found (M + H) + Ki (nM)b
1 Phac-Arg-Val-Arg-4-Amba 24.40 678.4/679.4 0.81
2 Acetyl-Val-Arg-4-Amba 18.58 446.3/447.3 2390
3 Biotin-Adoa-Val-Arg-4-Amba 24.62 775.4/776.5 4200
4 Phac-Arg-Pro-Arg-4-Amba 22.77 676.4/339.2a 36.7
5 Biotin-Adoa-Arg-Pro-Arg-4-Amba 21.36 929.5/930.6 38.3
6 Biotin-(Adoa)2-Arg-Pro-Arg-4-Amba 22.82 1074.6/1075.5 57.4
7 Biotin-(Adoa)3-Arg-Pro-Arg-4-Amba 24.07 1219.7/611.1a 15.1
8 Phac-Arg-Thr-Arg-4-Amba 21.40 680.4/341.3a 6.0
9 Biotin-(Adoa)2-Arg-Thr-Arg-4-Amba 22.53 1078.6/540.5a 9.0
a

(M+2H)2+/2.

b

Ki measurements were performed as described previously (Becker et al., 2010; Sielaff et al., 2011).