Table 2.
Demographic and clinical characteristics of the Study Group (n=56)
| Variable | INTRA-AMNIOTIC INFLAMMATION |
P value | |
|---|---|---|---|
| NO n=37 |
YES n=19 |
||
| Demographic characteristics | |||
| Age, years * | 27.9 [5.6] | 26.7 [7.6] | 0.522 |
| Parity † | 1 [0 – 1] | 1[0 – 1] | 0.933 |
| Gravidity † | 2 [1 – 3] | 2 [1 – 3] | 0.622 |
| Gestational age enrollment, weeks † | 30.3 [27.4 – 31.6] | 27.1 [24.7 – 28.9] | 0.014 |
| Ruptured membranes ‡ | 20 (54) | 7 (37) | 0.348 |
| History of preterm birth § | 10 (27) | 4 (21) | 0.751 |
| Steroid exposure during pregnancy ‡ | 30 (86) | 18 (95) | 0.243 |
| Prenatal antibiotic treatment ‡ | 25 (67) | 18 (95) | 0.041 |
| Outcome characteristics | |||
| Amniocentesis-to-delivery, days † | 4.9 [1.2 – 27.9] | 0.3 [0.2 –1.1] | < 0.001 |
| Gestational age delivery, weeks † | 32.3 [30.1 – 34.2] | 27.2 [25.3 – 29.3] | < 0.001 |
| Birthweight, grams † | 1,870 [1,450 – 2,270] | 955 [805 – 1,344] | < 0.001 |
| Cesarean delivery ‡ | 12 (32) | 8 (42) | 0.674 |
| Umbilical artery pH * | 7.30 [0.05] | 7.33 [0.08] | 0.407 |
| Umbilical artery base excess, mmols/L * | - 3.9 [3.4] | - 5.0 [3.9] | 0.526 |
| Apgar score at 1 minute † | 8 [7 – 9] | 7 [4 – 8] | 0.035 |
| Apgar score at 5 minutes † | 9 [8 – 9] | 8 [7 – 9] | 0.150 |
*
Data presented as mean and standard deviation [SD] and analyzed with Student t-test
†
Data presented as median [interquartile range] and analyzed with Mann-Whitney test
‡
Data presented as n (%) and analyzed by Chi square test
§
Data presented as n (%) and analyzed by Fisher’s exact test
Intra-amniotic inflammation was defined based on the proteomic Mass Restricted (MR) score. An MR score 0 (zero) indicates “no” inflammation. MR score 3-4 indicates “severe” inflammation (see reference 21&22).