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OX1R knockdown in the PVT increases dark phase locomotor activity but has no effects on body weight. (A) There are no differences in the changes in body weights, taken at 16, 52 and 71 days post-surgery, between OX1R knockdown and control groups. (B) OX1R knockdown rats exhibit significantly increased locomotor activity, as measured by total beam breaks in a 12-hr dark phase, when compared to control rats (* p<0.05).
