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Model of PIP2-mediated IQGAP1 activation. In response to receptor activation, PIPKIγ recruits IQGAP1 to the leading edge membrane of migrating cells. Then, PIP2 generated by PIPKIγ interacts with a PBM of IQGAP1 to block the autoinhibitory interaction between the GRD and RGCT domains. The relieved RGCT domain mediates actin polymerization by recruiting N-WASP and the Arp2/3 complex.
