Skip to main content
. 2013 Sep 6;32(19):2645–2656. doi: 10.1038/emboj.2013.194

Figure 3.

Figure 3

Effects of Spt6 depletion on transcription elongation. (A, B) On exceptionally long genes Spt6 inactivation causes an apparent processivity defect characterized by reduced pol II density at 3′ ends. (B) Average distributions of pol II in spt6-td normalized to WT (37°C+Dox) on protein-coding genes >4 kb long (Supplementary Table S1). (C–F) Reduced pol II occupancy at 5′ relative to 3′ ends in spt6-td compared to WT. (E, F) Average distributions of pol II in WT and spt6-td (37°C+Dox) at genes with low and intermediate levels of transcription (groups 1 and 2 as in Figure 2A) normalized to the average value in the body of the gene.