Fig. 1.

Aggregation of wild-type, ADAP^−/− and FcRg^−/− platelets and thromboxane B₂ release induced by CRP, collagen and U46619. Aggregation (A–I) and thromboxane B₂ (TxB₂) production (J–L) induced by collagen-related peptide (CRP) (A, D, G, J) collagen (B, E, H, K) and U46619 (C, F, I, L) in wild-type (WT), adhesion and degranulation-promoting adapter protein-deficient (ADAP^−/−) and Fc receptor γ-chain-deficient (FcRγ^−/−) platelets. Platelet aggregation is reported as rate (A–C), extent after 6 min (D–F), and the reciprocal of the time from the addition of agonist to the onset of the response (G–I) (mean ± standard error of the mean: n = 9 for aggregation; n = 5 for TxB₂ production).