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. 2013 Sep 20;4:2443. doi: 10.1038/ncomms3443

Figure 6. ERAP inhibits tumour growth in xenograft models of human ERα-positive breast cancer.

Figure 6

(a) ERAP inhibits tumour growth in a human breast cancer KPL-3C xenograft mouse model. The tumour volume represents the mean±s.e.m. of each group (n=5; **P<0.01 in two-sided Student’s t-test). (b) Real-time PCR was performed to determine the combined inhibitory effects of ERAP and tamoxifen on the expression of ERα target genes. The data are expressed the fold increase over untreated cells at 0 h (set at 1.0) and represent the mean±s.e.m. of each group (n=5; *P<0.05, **P<0.01, ***P<0.001 in two-sided Student’s t-test). (c) Immunoblot analyses were performed to evaluate the effects of ERAP on the phosphorylation levels of Akt, p42/44 MAPK and ERα proteins in tumours.