Figure 1.

The syntenic positions of Nod1 and Nod2 are highly conserved. The syntenic position of (A) Nod1 and (B) Nod2 were compared in 12 different vertebrate species. The three adjacent genes upstream and downstream of Nod1/2 are displayed. Each gene is represented by an individual block with yellow denoting a position on the forward strand and green a position on the reverse strand. A space indicates insufficient information to definitively identify the gene in that location. The red blocks in (B) indicate the absence of the Nod2 gene from the frog, anole lizard, and chicken genomes. Gene identities are as follows: Plekha8 – pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8; C7orf41 – chromosome seven open reading frame 41; znrf2 – zinc and ring finger 2; Nod1 – nucleotide-binding oligomerization domain containing 1; Ggct – gamma-glutamylcyclotransferase; Gars – glycyl-tRNA synthetase; Crhr2 – corticotrophin-releasing hormone receptor 2; Fkbp14 – FK506 binding protein 14; BT.25096 – corticotrophin-releasing factor receptor 2; E13Rik – RIKEN cDNA 241066E13 gene; Entpd3 – ectonucleoside triphosphate diphosphohydrolase 3; Efcab1 – EF-hand calcium binding protein; Eaf1 – ELL-associated factor 1-like; Rpl14 – ribosomal protein L14; Mettl6 – methyltransferase-like protein 6; Gpatch3 – G patch domain containing 3; Sacm1l – SAC1 suppressor of actin mutations 1-like; Fzd1 – frizzled homolog 1; Cdk14 – cyclin-dependent kinase 14; Brd7 – bromodomain containing 7; Nkd1 – naked cuticle homolog 1; Snx20 – sorting nexin 20; Nod2 – nucleotide-binding oligomerization domain containing 1; Cyld – ubiquitin carboxyl-terminal hydrolase; Sall1 – sal-like 1; Gapdh – glyceraldehydes 3-phosphate dehydrogenase; Nkx6-2 – uncharacterized protein; Gm6625 – protein Gm6625; Arl2bp – ADP-ribosylation factor-like 2 binding protein; Rspry1 – ring finger and SPRY domain containing 1; Fam192a – family with sequence similarity 192, member A; Adcy7 – adenylate cyclase 7.