Table 1. Evolutionary divergence in thermal sensitivity and conservation in electrophile sensitivity of TRPA1.
| Species | Temperature sensitivity | Electrophile sensitivity | Identity to hTRPA1 (%) | Accession number |
|---|---|---|---|---|
| Mosquito | Heat | Yes | 35 | XP_001843993 |
| Fruit fly (dTRPA1) | Heat | Yes | 36 | CG5751 |
| Rattle snake | Heat | Yes | 63 | ADD82930 |
| Frog | Heat | Yes | 56 | AB693190 |
| Lizard | Heat | Yes | 63 | AB693189 |
| Mouse | Cold | Yes | 79 | NP_808449 |
| Rat | Cold | Yes | 79 | NP_997491 |
| rhesus monkey | Insensitive | Yes | 97 | XP_001083172 |
| Human | Insensitive | Yes | — | NM_0073332 |
All channels shown above derive from TRPA1 clade, the common ancestors of vertebrate and invertebrates.