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. 2013 Sep;5(Suppl 4):S440–S445. doi: 10.3978/j.issn.2072-1439.2013.07.09

Table 1. Classification of carcinogenic agents according to the International Agency for Research on Cancer.

Group Classification Parameter Number of agents
1* Carcinogenic to humans Sufficient evidence of carcinogenicity in humans and in experimental animals 111
2A Probably carcinogenic to humans Limited evidence of carcinogenicity in humans and sufficient evidence of carcinogenicity in experimental animals 65
2B Possibly carcinogenic to humans Limited evidence of carcinogenicity in humans and less than sufficient evidence of carcinogenicity in experimental animals 274
3 The agent is not classifiable as to its carcinogenicity to humans Inadequate evidence of carcinogenicity in humans and in experimental animals 504
4 The agent is probably not carcinogenic to humans Evidence suggesting lack of carcinogenicity in humans and in experimental animals 1

*An agent can be included in Group 1 in the absence of sufficient evidence for carcinogenicity in humans but there is sufficient data of carcinogenicity in experimental animals and strong evidence that the agent acts through a similar mechanism of carcinogenicity in humans.