Table 1. Older series of patients with Pancoast tumors who underwent treatment with a variety of protocols - cumulative results.
| Series/years | No. of patients | pT stage | pN stage | Induction and/or adjuvant therapy | Postop. mortality | Completeness of resection and associated 5-year survival (%) | 5-year survival |
|---|---|---|---|---|---|---|---|
| Paulson et al. [1956-1978] | 64 | N/A | N/A | Preop radiotherapy =64 | N/A | N/A | 30% |
| (44% 5-year survival without nodal involvement and 0% with hilar or mediastinal nodal involvement) | |||||||
| Miller et al. [1971-1977] | 26 | N/A | N0 =20 | Preop radiotherapy =26 | 3.8% | Complete resection: 22 (NA) | 32% |
| N1 =1 | Incomplete resection: 4 (NA) | ||||||
| N2/hilar =5 | |||||||
| √Ginsberg et al. [1974-1991] | 124 | T3 =101 | N0 =94 | None (primary surgery) =7 | 4% | Complete resection: 69 (41%) | 30% |
| T4 =23 | N1 =3 | Preop radiotherapy =79 | Incomplete or no resection: 55 (9%) | ||||
| N2 =20 | Preop and postop radiotherapy =10 | ||||||
| N3 =7 | Postop radiotherapy =28 | ||||||
| Brachytherapy =102 | |||||||
| Hagan et al. [1975-1992] | 34 | T3 =28 | N0 =28 | Preop radiotherapy =16 | 0% | Complete resection: 27 (N/A) | 33% |
| T4 =6 | N1 =2 | Preop + postop radiotherapy =11 | Incomplete resection (R1): 7 (N/A) | ||||
| N2 =3 | Postop radiotherapy only =7 | ||||||
| N3 =1 | |||||||
| †Komaki et al. [1975-1994] | 62 | N/A | N/A | None (primary surgery) =5 | N/A | Complete resection =33 (55%) | N/A |
| Preop chemotherapy ± radiotherapy =12 | Incomplete resection (R2) =29 (18%) | ||||||
| Postop radiotherapy ± chemotherapy =28 | |||||||
| Preop and postop radiotherapy ± chemotherapy =17 | |||||||
| Muscolino et al. [1984-1988] | 15 | T3 =11 | N0 =10 | Preop radiotherapy =11 | 6.6% | Complete without N2 disease =7 (57%) | 26.6% |
| T4 =4 | N1 =1 | (Postop radiotherapy in patients with primary surgery or incomplete resection) | Incomplete or N2 disease =8 (0%) | ||||
| N2 =4 | |||||||
| Martinod- et al. [1983-1999] | 139 | T3 =94 | N0 =108 | Preop radiotherapy =41 | 7.2% | Complete resection =113 (NA) | 35% |
| T4 =45 | N1 =12 | Preop chemotherapy =5 | Incomplete resection =26 (NA) | ||||
| N2 =18 | Preop radiotherapy + chemotherapy =12 | ||||||
| N3 =1 | None (primary surgery) =98 | ||||||
| Postop radiotherapy =58 Postop chemotherapy =3 | |||||||
| Postop radiotherapy + chemotherapy =32 | |||||||
| None =36 | |||||||
| Alifano et al. [1988-2002] | 67 | T3 =61 | N0 =49 | Preop chemotherapy + radiotherapy =4 | 8.9% | Complete resection=55 (44.9%) | 36.2% |
| T4 =6 | N1 =6 | Preop chemotherapy =3 | Incomplete resection =12 (0%) | ||||
| N2 =6 (available only in patients with T3 tumors) | None =60 | ||||||
| Postop radiotherapy =42 | |||||||
| Postop radiotherapy + chemotherapy =9 | |||||||
| Postop chemotherapy =2 | |||||||
| None =7 | |||||||
| Koizumi et al. [1988-2003] | 16 | T4=7 | N0=7 | Preop radiotherapy =9 | 0% | Complete resection =11 (59.3%) | 31% |
| T3=9 | N1=1 | Preop radiotherapy + chemotherapy =3 | Incomplete resection =5 (0%) | ||||
| N2=7 | None =4 | ||||||
| N3=1 | Postop radiotherapy =1 | ||||||
| Postop radiotherapy + chemotherapy =9 | |||||||
| Postop chemotherapy =2 | |||||||
| None =4 | |||||||
| †Gandhi et al. [1990-1998] | 17 | T4* | N0 =12 | Preop radiotherapy =4 | 0% | Complete resection =11 (80% 2-year) | N/A |
| N1 =3 (hilar) | Preop chemotherapy =3 | Incomplete resection =6 (0% 2-year) | |||||
| Isolated N3 =2 | Postop radiotherapy =13 | ||||||
| Postop chemotherapy =4 | |||||||
| √Rusch et al. [1992-1998] | 101 | T3 =63 | N/A | Various types of preop treatment | Complete resection for T3 tumors =46 (73%) | N/A | |
| T4 =32 | Complete resection for T4 tumors =5 (15%) | ||||||
| Attar et al. [1995-1997] | 67 surgical patients | N/A | N/A | None (primary surgery) =28 | N/A | Complete resection=55 (42% median) | 26% |
| Preop radiotherapy =28 | Incomplete resection =12 (37.5% median) | ||||||
| Preop radiotherapy + chemotherapy =11 | |||||||
| Postop radiotherapy =16 |
pT, pathologic T stage; pN, pathologic N stage; Preop, preoperative; postop, postoperative; radio, radiotherapy; chemo, chemotherapy; N/A, non applicable; R2, incomplete resection with gross residual disease left behind; T4*, with vertebral invasion; √, †, Series reported from the same Institute.