Table 1.

Comparison between the effective dose extrapolated from monkeys for nine different tracers and the actual effective dose measured in humans

Tracer	Dose from monkeys (µSv/MBq)	Reference	Dose from humans (µSv/MBq)	Reference	% difference as compared to monkey estimatesa	% difference as compared to the human meanb
11C-BTA-1	7.4	Parsey et al. (2005) [7]	4.3	Thees et al. (2007) [8]	−72.1	−25.1
11C-(R)-Rolipram	6.6	Sprague et al. (2008) [2]	4.8	Sprague et al. (2008) [2]	−37.5	−16.4
11C-DASB	6.2	Tipre et al. (2004) [9]	7.0	Lu et al. (2004) [10]	11.4	21.9
11C-PBR28	10.3	Brown et al. (2007) [3]	6.6	Brown et al. (2007) [3]	−56.1	14.9
11C-CUMI-101	6.9	Parsey (unpubl.)	5.3	Hines et al. (2011) [11]	−30.2	−7.7
11C-MePPEP	6.6	NIMH/SNIDD [12]	4.6	Terry et al. (2010) [13]	−43.5	−19.9
11C-dLop	9.4	Liow et al. (2009) [14]	7.8	Seneca et al. (2009) [15]	−20.5	35.8
11C-(R)-PK11195	5.3	Our unpubl. data	5.0	Hirvonen et al. (2010) [16]	−6.0	−13.0
			4.6	Kumar et al. (2010) [17]	−13	−19.9
11C-raclopride	6.7	Herscovitch et al. (1997) [18]	6.3	Slifstein et al. (2006) [19]	−6.3	9.7
			6.7	Ribeiro et al. (2005) [20]	0	16.6
Mean±SD	7.3±1.6		5.7±1.2		−29.0±26.5	0±21.7

^aObtained for each tracer j by: (human dose_j − monkey dose_j)*100/human dose_j

^bObtained for each tracer j by: (human dose_j − mean human dose)*100/mean human dose