Table 1.
Characteristics of persons enrolled to the study
| HIV-1 infected | HIV-1 uninfected | p-value | |
|---|---|---|---|
| N | 15 | 21 | |
| Sex: female/male, n | 11/4 | 13/8 | 0.564 |
| Age, mean years (range) | 34.3 (24–51) | 32.7 (21–55) | 0.531 |
| CD4, median CD4 cells/μL (range) | 226 (61–595) | 786 (461–1225) | <0.001a) |
| Blood CD4+, median CD4+ as % of CD3+ T cells (range) | 10.0 (3.45–28.9) | 42.4 (9.46–67.8) | <0.001a) |
| BAL CD4+, median CD4+ as % of CD3+ T cells (range) | 7.7 (1.33–31.30) | 37.7 (12.5–78.7) | <0.001a) |
| Blood viral load, median RNA copies/mL, (range) | 22 000 (590–660 000) | ||
| BAL viral load, median RNA copies/mL, (range) | 1964 (855–709 088) | ||
| Response to ESAT-6/CFP-10, blood: positive/negative | 10/5 | 11/10 | 0.190b) |
a)
Differences between the HIV-1-infected and -uninfected groups were compared using the Mann–Whitney U-test.
b)
Difference of ESAT-6/CFP-10-induced IFNγ-response in PBMCs between HIV-1-infected and -uninfected groups was compared using Fisher’s exact test of probability.