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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Cancer Res. 2013 Aug 13;73(19):5974–5984. doi: 10.1158/0008-5472.CAN-13-1384

Table 2. p53 stabilization mediates apoptosis induced by Notchl ablation (related to Figure 4B).

Percent of A549 cells in phases of the cell cycle after Notch1 or/and p53 knockdown. 72h after transfection cells were fixed and stained with propidium iodide (PI) and analyzed for DNA content. The experiment was repeated 3 times.

G1 S G2/M Sub-G1/Apop
Non-targeting 70.9 13.2 14.4 1.39
N1 siRNA 43.2 12.9 21.6 16.4
p53 siRNA 57.7 13.2 18.3 9.2
N1+p53 siRNA 51.4 15.1 22.1 9.2