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Signaling through NLR receptors in lupus. Intracellular DNA following microbial infection or phagocytosis of immune complexes can potentially trigger the assembly of NLRs. The nucleic acid-induced signaling pathway converges on the adaptor STING and the kinase TBK1, which phosphorylates IRF3 to mediate downstream signaling events leading to transcriptional induction of type 1 IFN and other inflammatory cytokines.
