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. 2013 Aug 11;63(1):29–47. doi: 10.1111/prd.12027

Table 1.

Effect of extracellular matrix mutations in the periodontium

Ligand Periodontal ligament Human disease Mouse model Periodontal ligament phenotype Reference(s)
Collagen
Collagen I Ehlers–Danlos syndrome type VIIa/b (1)
Collagen XII Col12a1/ MXIINC3(-) TG ND + (58, 115)
Proteoglycans
Decorin Stromal corneal dystrophy Dcn/ + (mouse) ND (human) (23, 33)
Lumican Lum/ + (28)
Fibromodulin Fmod/ + (140)
Glycoproteins
Fibrillin-1 Marfan syndrome type I Fbn1/ Fbn1Tsk + (108, 133)
SPARC Sparc/ + (102)
Osteopontin Spp1/ (77)
Periostin Postn/ + (120)
Transforming growth factor beta-induced Granular corneal dystrophy Tgfbi/ ND (66, 167)
Tenascin-W ND (100)
Gene locus: 12p13 Ehlers–Danlos syndrome type VIII + (16)
+

present

none

ND, not determined.