. Author manuscript; available in PMC: 2014 Oct 1.

Published in final edited form as: Biochem Pharmacol. 2013 Aug 17;86(7):904–913. doi: 10.1016/j.bcp.2013.08.004

Table 3.

Effect of ABC transporter modulators on the chemosensitivity of BI 2536 in ABCB1- or ABCG2-overexpressing cell lines

Cell lines	IC₅₀ (nM)^a

	BI 2536	BI 2536 + tariquidar (1 μM)	BI 2536 + FTC (3 μM)	BI 2536 + nilotinib (0.5 μM)	BI 2536 + lapatinib (0.3 μM)
KB-3-1	1.48 ± 0.53	1.35 ± 0.49	N.D	0.83 ± 0.40	0.89 ± 0.41
KB-V-1	281.24 ± 31.57	2.09 ± 0.77^***	N.D	11.44 ± 1.87^***	11.83 ± 2.41^***
S1	24.30 ± 4.75	N.D	27.18 ± 2.54	13.94 ± 2.69^*	25.14 ± 8.11
S1-M1-80	261.06 ± 48.25	N.D	32.34 ± 12.73^**	18.53 ± 3.03^***	13.21 ±4.20^***
MCF7	5.11 ± 1.47	N.D	8.37 ± 2.59	4.24 ± 1.36	9.68 ± 3.19
MCF7-FLV1000	393.18 ± 74.83	N.D	41.99 ± 28.36^**	124.21 ± 9.57^**	128.31 ± 8.49^**
pcDNA-HEK293	2.75 ± 0.67	1.47 ± 0.50	2.62 ± 0.72	2.13 ± 0.81	1.95 ± 0.59
MDR19-HEK293	85.50 ± 13.67	1.30 ± 0.46^***	N.D	7.78 ± 1.77^***	29.61 ± 8.25^**
R482-HEK293	25.97 ± 4.95	N.D	3.95 ± 1.43^**	6.26 ± 1.83^**	7.02 ± 2.31^**

Abbreviation: N.D, not determined.

IC₅₀ values are mean ± SD in the presence and absence of BI 2536 or other tested compounds. The IC₅₀ values were calculated from dose-response curves obtained from three independent experiments.

P < 0.05;

^**

P < 0.01;

^***

P < 0.001