Figure 1.

MyD88 prolongs survival during pulmonary tularemia. WT and MyD88 KO mice were infected intratracheally with 100 CFU of Schu S4. A: Survival was assessed as described in Materials and Methods. There were nine mice in the MyD88 KO group and eight mice in the WT group, combined from two independent experiments. Statistical significance was determined using a log-rank test. The morbidity of the mice over the course of the infection was monitored using a clinical score (B) and weight loss (C). These data represent the means ± SEM for two independent experiments. Significance was determined using a two-tailed Student’s t-test to compare clinical score and weight loss. ^∗P < 0.05.