Figure 3.

Loss of MyD88 reduces cytokine production in response to F. tularensis. Cytokine response was assessed in the lungs (A), serum (B), and spleens (C) of WT (black bars) and MyD88 KO (grey bars) mice on day 4 after infection. The data are representative of three independent experiments with four to five mice per group for the lungs and sera, and two independent experiments with three mice per group for the spleens. Significance was determined using a Student’s t-test. ^∗∗P < 0.01, ^∗∗∗P < 0.001. ND, value is below detectable limits.