Figure 4.

Altered organ pathology in MyD88 KO mice during F. tularensis infection. Lungs (A, D, G, and J), spleens (B, E, H, and K), and livers (C, F, I, and L) were harvested from MyD88 KO and WT mice on day 4 after infection, fixed in formalin, and then embedded in paraffin. H&E staining was performed to assess histopathological changes within the organs. The images shown are representative of two lungs, two spleens, and two livers for PBS-treated mice. Six lungs, five spleens, and five livers were collected during three independent experiments for Schu S4–treated WT and MyD88 KO mice. Scale bars: 100 μm. Insets are digital magnifications of the boxed areas measuring 50 μm square.