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. 2013 Oct;183(4):1156–1168. doi: 10.1016/j.ajpath.2013.06.022

Figure 3.

Figure 3

Sema3a-induced glomerular ultrastructural abnormalities are reversible. A and D: TEM reveals normal glomerular filtration barrier ultrastructure in uninduced Sema3a+ kidneys. B and E: Sema3a podocyte overexpression induces foot process effacement, mesangial matrix expansion, and GBM lamination. C and F: At 2 weeks after doxycycline removal (+/−dox), the Sema3a-induced foot process effacement, GBM, and endothelial cell abnormalities resolve. G: Morphometry confirms reversibility of foot process effacement. Data are expressed as means ± SEM. ∗P < 0.05. Scale bars: 1 μm (A–C); 200 nm (D); 500 nm (E and F).