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. 2013 Oct;183(4):1293–1305. doi: 10.1016/j.ajpath.2013.06.026

Figure 2.

Figure 2

Lysyl oxidase (LOX) controls glioblastoma growth in mouse brain. A: Representative micrographs show brain tumors (arrows) growing in mouse brain for 12 days after implantation of U87MG cells. Treatment with β-aminopropionitrile (BAPN) was started on the day of tumor implantation. Light micrographs show brain tumor growing in brains of control and BAPN-treated mice. Quantitation shows size of tumor growing in mouse brain (n = 8). B: Representative micrographs show brain tumors (arrows) growing in mouse brain for 12 days after implantation of U87MG cells. Treatment with BAPN was started 4 days after tumor implantation. Light micrographs show brain tumor growing in brains of control or BAPN-treated mice. Quantitation shows size of tumor growing in mouse brain (n = 8). C: Relative LOX activity was measured in mouse brain tumors treated with BAPN (n = 8). D: Micrographs show representative brain tumors harvested 12 days after implantation of U87MG cells. Weight of brain tumors treated with BAPN was measured (n = 8). ∗P < 0.05. Error bars represent SEM. Scale bar = 5 mm (A and B, top panels); 1 mm (A and B, bottom panels).