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. 2013 Oct;183(4):1209–1222. doi: 10.1016/j.ajpath.2013.06.017

Figure 10.

Figure 10

Renal histologic features in mice that received adoptively transferred gal3−/− or gal3+/+ DCs exposed to C. albicans. gal3−/− or gal3+/+ BMDCs were left untreated (naive) or were pulsed with C. albicans for 1 hour and then were adoptively transferred into gal3+/+ mice i.v. Six days after transfer (6 d.p.i.), kidneys were harvested and fixed in formalin. Tissue sections were stained with H&E (A) and PAS (B). A: Adoptive transfer of gal3−/− DCs promoted increased levels of cellular infiltration into kidneys compared with gal3+/+ DCs after infection. Sites of cellular infiltration are indicated by orange dashed lines. Objectives: 10× (top); 40× (bottom). Scale bars: 250 μm (top); 50 μm (bottom). B: Higher C. albicans burden in mice that received adoptively transferred gal3+/+ DCs. Fungi are indicated by orange dashed lines.Objective, 40×. Scale bar = 50 μm. Representative images are shown. C: Higher levels of neutrophil infiltration in kidneys of mice receiving adoptively transferred gal3−/− DCs. Neutrophils were identified by their polymorphic nuclei and cell size and were enumerated from five nonoverlapping high-power fields. Means are depicted by the horizontal lines.