Figure 3.

Differential IL-23 production by gal3^−/− (black bars) and gal3^+/+ (white bars) DCs contributed to differences in Th17 induction. ELISA of cytokines in OVA-curdlan DC–T-cell (OT-II) co-cultures after the addition of neutralizing anti–IL-23p19, anti–IL-12/23p40, or isotype control antibodies on day 0. The co-cultures were maintained for 3 days. Data are given as means ± SD and are representative of at least four independent experiments. ^∗P < 0.05, ^∗∗P < 0.01.