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. 2013 Oct;183(4):1209–1222. doi: 10.1016/j.ajpath.2013.06.017

Figure 9.

Figure 9

Galectin-3 in DCs regulated antifungal immunity in vivo. Gal3−/− (black bars) or gal3+/+ (white bars) DCs mixed with live C. albicans were adoptively transferred into wild-type mice by i.v. injection. A: Kidneys of C. albicans–infected mice were collected on days 3 and 6 after adoptive transfer of gal3+/+ and gal3−/− DCs and infection. Kidneys were homogenized, and cytokine levels in the supernatants of the homogenates were determined. The experiment was performed three times, with two to four mice included per group in each experiment. B: Real-time qPCR for indicated mRNAs in splenic CD4+ cells from mice that received C. albicans–exposed gal3−/− or gal3+/+ DCs. The relative mRNA fold induction was calculated based on the fold induction of nontreated samples. Three to four mice were included in each group. The experiment was repeated three times. C: Fungal burdens [colony-forming units (CFUs) per gram of tissue] in brains and kidneys of mice that received DCs were collected on days 3 and 6 after infection. Nine to 10 mice were included in each group. Data are given as means ± SD. ∗P < 0.05.