Skip to main content
. 2002 Jul 1;71(2):375–388. doi: 10.1086/341963

Figure 7.

Figure 7

Evaluation of replication timing of sequences flanking the pericentric inversion breakpoints with BACs and PACs from human 17q21.3 (RP1-81K2 and RP11-613C6) and from human 17p13 (RP11-404G1 and RP11-1D5) as FISH probes (see fig. 3 for position of BACs relative to the breakpoint). The percentage of two doublet signals was determined in BrdU-labeled S-phase nuclei of fibroblastlike cells from chimpanzee (chimpanzee cell line CP132) and primary human foreskin fibroblasts. FISH analysis was also performed with BAC RP11-133K23 as reference probe for a late-replicating genomic region and with BAC RP11-869B15 for an early-replicating genomic region. D/D = two doublets; HSA = Homo sapiens; PTR = Pan troglodytes.