Fig. 3.

Cenersen treatment decreased p53 expression in primary MDS erythroid progenitors. (A) Representative photomicrograph of p53 immunofluorescence in del(5q) MDS progenitors, with p53 staining shown in green and DAPI in blue (magnification: Upper, ×630; Lower, ×3,780). (B–D) Nuclear and cytoplasmic p53 FI levels in del(5q) MDS (n = 10; B), nondel(5q) MDS (n = 11; C), and normal controls (n = 6; D) with cenersen and control oligonucleotide treatment. Cenersen, black bars; control oligonucleotide, open bars. Values are mean FI ± SEM. P values were calculated by Wilcoxon signed-rank test: *P < 0.05; NS, not significant.