Fig. 5.

Lenalidomide plus dexamethasone treatment suppresses p53 expression and promotes erythroid expansion. Bone marrow biopsies of treated patients were stained with p53 (A) and spectrin (B), with percentage of positive staining shown. Representative micrographs of a single responder are shown at both baseline (Left) and time of response (Right). (Upper) p53 staining was decreased between baseline and the time of response. (Lower) Spectrin staining increased from baseline to the time of response (magnification: ×600). Results are means ± SEM. P values were calculated by t-test: *P < 0.05; NS, not significant.