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. 2013 Sep 17;110(40):16241–16246. doi: 10.1073/pnas.1310300110

Fig. 1.

Fig. 1.

Temperature regulation in TRα1+m mice. (A) Core body temperature was measured using radiotelemetry, revealing a significant interaction over a 24-h period in TRα1+m mice (solid circles) compared with wild-type controls (open circles; two-way ANOVA, P < 0.01). (B) This translated to significantly lower mean TRα1+m body temperature in the dark phase (two-way ANOVA with Bonferroni post hoc test, **P < 0.01; ns, P > 0.05). (C and D) Infrared thermography was used to quantify heat generation from the interscapular brown fat depot (*P < 0.05) and heat dissipation from the tail (*P < 0.05). (E and F) Wild-type and TRα1+m mice were analyzed in metabolic cages for oxygen consumption, showing hypermetabolism in the mutants (absolute values in E and relative to body weight in F, two-way ANOVA with Bonferroni post hoc test, *P < 0.05, ***P < 0.001). The number of animals is given in parentheses in the respective experiments.