Table 2.
Overview of pentraxin receptors.
| Receptor | Cells | Other ligands | Functions | |
|---|---|---|---|---|
| FcγRI (CD64) | Monocytes, macrophages, DC, inducible on PMN | Activating | High affinity for IgG | Antibody-dependent cell-mediated cytotoxicity Phagocytosis |
|
| ||||
| FcγRIIA/C (CD32A/C) | Monocytes, macrophages, DC neutrophils, platelets | Activating | IgG | Antibody-dependent cell-mediated cytotoxicity Phagocytosis Platelet activation |
|
| ||||
| FcγRIIB (CD32B) | B lymphocytes, macrophages, DC | Inhibitory | IgG | Regulation of responses through immunoreceptors |
|
| ||||
| FcγRIIIA (CD16A) | Macrophages, some monocytes, NK cells | Activating | IgG | Antibody-dependent cell-mediated cytotoxicity Phagocytosis |
|
| ||||
| FcγRIIIB (CD16B) | PMNs | GPI-linked | IgG | Immune complex binding Activation of FcγRIIA |
|
| ||||
| FcαRI (CD89) | Monocytes, macrophages, DC neutrophils, platelets | Activating/inhibitory | IgA | Phagocytosis Regulation of responses through other receptors |