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. Author manuscript; available in PMC: 2014 Aug 27.
Published in final edited form as: Biochemistry. 2013 Aug 15;52(34):5708–5722. doi: 10.1021/bi400804z

Figure 3. The conserved region of EcMscS and TtMscS monomers in different conformations.

Figure 3

A single monomer of (A) EcMscS (aa 27-175) in a nonconducting state (2OAU, Steinbacher, 2007); (B) TtMscS (aa 13-175) in a nonconducting state (3UDC, Zhang, 2012); (C) EcMscS A106V (aa 25-175) in an open state (2VV5, Wang, 2008). (D) Superposition of panel A with a single monomer of EcMscS (27-175) in an open state (4HWA, Lai, 2013). The kink-forming residues G113 (EcMscS) and G109 (TtMscS) are represented as blue spheres and the A106V mutation as a red sphere. The vapor-lock residues L105 and L109 are labeled in yellow. F68 and L111, residues proposed to mediate the TM2-TM3 interaction (Belyy, 2010) are labeled magenta. Images were generated with VMD software (University of Illinois).