Table 3.

Expression pattern of various proteins in the sera of various breast cancer groups.

Sr. no.	Protein/s	Expression level w.r.t. normal	Breast cancer patients groups w.r.t. treatment/HCV infection (% age) (A = Nonchemotherapeutically treated, B = Chemotherapeutically treated, C = HCV positive)			P-value (X2-test)	Breast cancer patients groups w.r.t. type of breast cancer (% age) (A = Infiltrating/invasive duct carcinoma, B = in-situ Duct carcinoma, C = Unknown)			P-value (X2-test)
			A (n = 32)	B (n = 8)	C (n = 7)		A (n = 22)	B (n = 7)	C (n = 14)
1.	SEB1a = Haptoglobin, SEB1b = Complement component C8 gamma chain	Down regulation	34.37	62.500	100.00	0.005	40.91	85.71	42.86	0.102
		Up-regulation	65.63	37.50	–		59.09	14.29	57.14
2.	SEB2 = Transthyretin	Down-regulation	56.25	87.50	100.00	0.035	72.73	71.43	57.14	0.605
		Up-regulation	43.75	12.50	–		27.27	28.57	42.86
3.	SEB3 = Transthyretin (modified)	Only expressed in diseased subjects	28.13	37.50	–	0.211	27.27	14.29	7.14	0.302
4.	SEB4 = Hemoglobin subunit β	Up-regulation	3.13	–	–	0.787	–	–	7.14	0.346
		No change	96.88	100.00	100.00		100.00	100.00	92.86
5.	SEB5a = Serum amyloid A protein, SEB5b = Albumin, SEB5c = Hemoglobin subunit β	Down-regulation	31.25	37.50	71.43	0.140	36.36	42.86	42.86	0.190
		Up-regulation	68.75	62.50	28.57		63.64	57.14	57.14
6.	SEB6a = Complement C3 SEB6b = Inter-alpha-trypsin inhibitor heavy chain H4	Down-regulation	34.38	12.50	85.71	0.048	31.82	57.14	28.57	0.595
		Up-regulation	62.50	87.50	14.23		63.64	42.86	71.43
		No change	3.13	–	–		4.55	–	–
7.	SEB7a = Serum albumin SEB7b = Complement C4-A	Down-regulation	46.88	75.00	85.71	0.093	54.55	71.43	50.00	0.470
		Up-regulation	53.13	25.00	14.29		45.45	28.57	50.00
8.	SEB8a = Ig Kappa chain c-region SEB8b= Apolipoprotein A1	Down-regulation	28.12	62.50	85.71	0.032	40.91	71.42	35.71	0.239
		Up-regulation	65.63	25.00	14.29		50.00	14.29	64.29
		No change	6.25	12.50	–		9.09	14.29	–