Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Inhibition by pyrazole-based compounds 12–17 (Kiyonaka et al., 2009)
| Figure 3 compounds | IC50 (μM) | |||||
|---|---|---|---|---|---|---|
| TRPC1 | TRPC3 | TRPC4 | TRPC5 | TRPC6 | TRPC7 | |
| 12 (Pyr2) | n.d. | 4.2 | n.d. | 0.1–1 | 1–10 | 1–10 |
| 13 (Pyr3) | n.d. | 0.5 | n.d. | >10 | >10 | >10 |
| 14 (Pyr4) | n.d. | 0.3–3 | n.d. | >10 | 1–10 | 1–10 |
| 15 (Pyr5) | n.d. | 0.1–1 | n.d. | >10 | >10 | >10 |
| 16 (Pyr6) | n.d. | 18.5 | >10 | >10 | >10 | n.d. |
| 17 (Pyr10) | n.d. | 0.7 | >10 | >10 | >10 | n.d. |
n.d., not determined; TRPC, Transient Receptor Potential Canonical.
